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Research article summary:
Early postnatal development of sensory gating.
Abstract Extract:
Sensory gating represents the nervous systems ability to inhibit responding to irrelevant environmental stimuli. In order to characterize the early development of acoustic sensory gating, suppression of auditory evoked potential component P1 (i.e. P50) ... (Full abstract text below) Published 2003Apr
in Journal: Neuroreport
(Language : eng)
Full Pubmed Extract
This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:
1. Neuroreport.
2003 Apr;14(5):693-7
Early postnatal development of sensory gating.
Kisley MA, Polk SD, Ross RG, Levisohn PM, Freedman R
Schizophrenia Research Center, Denver Veteran's Affairs Medical Center, Colorado, USA. michael.kisley@uchsc.edu
Sensory gating represents the nervous system's ability to inhibit responding to irrelevant environmental stimuli. In order to characterize the early development of acoustic sensory gating, suppression of auditory evoked potential component P1 (i.e. P50) in response to paired clicks was measured during REM sleep in healthy infants (1-4 months) that were without genetic risk for disrupted sensory gating function (i.e. having a relative with schizophrenia). As a group, the subjects exhibited significant response suppression. A correlation between increasing age and stronger response suppression was uncovered, even within this restricted age range. Parallel changes in sleep physiology could not be ruled out as the explanation for this change. Nevertheless, these results demonstrate that the neural circuits underlying sensory gating are functional very early in postnatal development.
PMID : 12692465 [PubMed - Indexed for MEDLINE]
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Full Author Information
| First Name | LastName | Initials |
| Michael A | Kisley | MA |
| Sherrie D | Polk | SD |
| Randal G | Ross | RG |
| Paul M | Levisohn | PM |
| Robert | Freedman | R |
Affiliation: Schizophrenia Research Center, Denver Veteran's Affairs Medical Center, Colorado, USA. michael.kisley@uchsc.edu
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MESH categories and related page links
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Category links from this article:- Acoustic Stimulation
- Age Factors
- Auditory Pathways - physiology
- Auditory Threshold - physiology
- Evoked Potentials, Auditory - physiology
- Humans
- Infant
- Neural Inhibition - physiology
- Reaction Time - physiology
- Reference Values
- Sleep, REM - physiology
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