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Research article summary:
Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm.
Abstract Extract:
OBJECTIVE: Dysfunctional attitudes are negatively biased assumptions and beliefs regarding oneself, the world, and the future. In healthy subjects, increasing serotonin (5-HT) agonism with a single dose of d-fenfluramine lowered dysfunctional attitudes. ... (Full abstract text below) Published 2003Jan
in Journal: Am J Psychiatry
(Language : eng)
Full Pubmed Extract
This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:
1. Am J Psychiatry.
2003 Jan;160(1):90-9
Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm.
Meyer JH, McMain S, Kennedy SH, Korman L, Brown GM, DaSilva JN, Wilson AA, Blak T, Eynan-Harvey R, Goulding VS, Houle S, Links P
Vivian M. Rakoff PET Imaging Centre, Clarke Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College St., Toronto, ON, M5T 1R8, Canada. jmeyer@camhpet.on.ca
OBJECTIVE: Dysfunctional attitudes are negatively biased assumptions and beliefs regarding oneself, the world, and the future. In healthy subjects, increasing serotonin (5-HT) agonism with a single dose of d-fenfluramine lowered dysfunctional attitudes. To investigate whether the converse, a low level of 5-HT agonism, could account for the higher levels of dysfunctional attitudes observed in patients with major depression or with self-injurious behavior, cortex 5-HT(2) receptor binding potential and dysfunctional attitudes were measured in patients with major depressive disorder, patients with a history of self-injurious behavior, and healthy comparison subjects (5-HT(2) receptor density increases during 5-HT depletion). METHOD: Twenty-nine healthy subjects were recruited to evaluate the effect of d-fenfluramine or of clonidine (control condition) on dysfunctional attitudes. Dysfunctional attitudes were assessed with the Dysfunctional Attitude Scale 1 hour before and 1 hour after drug administration. In a second experiment, dysfunctional attitudes and 5-HT(2) binding potential were measured in 22 patients with a major depressive episode secondary to major depressive disorder, 18 patients with a history of self-injurious behavior occurring outside of a depressive episode, and another 29 age-matched healthy subjects. Cortex 5-HT(2) binding potential was measured with [(18)F]setoperone positron emission tomography. RESULTS: In the first experiment, dysfunctional attitudes decreased after administration of d-fenfluramine. In the second experiment, in the depressed group, dysfunctional attitudes were positively associated with cortex 5-HT(2) binding potential, especially in Brodmann's area 9 (after adjustment for age). Depressed subjects with extremely dysfunctional attitudes had higher 5-HT(2) binding potential, compared to healthy subjects, particularly in Brodmann's area 9. CONCLUSIONS: Low levels of 5-HT agonism in the brain cortex may explain the severely pessimistic, dysfunctional attitudes associated with major depression.
PMID : 12505806 [PubMed - Indexed for MEDLINE]
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Full Author Information
| First Name | LastName | Initials |
| Jeffrey H | Meyer | JH |
| Shelley | McMain | S |
| Sidney H | Kennedy | SH |
| Lorne | Korman | L |
| Gregory M | Brown | GM |
| Jean N | DaSilva | JN |
| Alan A | Wilson | AA |
| Thomas | Blak | T |
| Rahel | Eynan-Harvey | R |
| Verdell S | Goulding | VS |
| Sylvain | Houle | S |
| Paul | Links | P |
Affiliation: Vivian M. Rakoff PET Imaging Centre, Clarke Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College St., Toronto, ON, M5T 1R8, Canada. jmeyer@camhpet.on.ca
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MESH categories and related page links
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Category links from this article:- Adolescent
- Adult
- Attitude
- Brain Mapping
- Cerebral Cortex - drug effects, physiopathology, radionuclide imaging
- Clonidine - pharmacology
- Depressive Disorder, Major - drug therapy, physiopathology, radionuclide imaging
- Female
- Fenfluramine - pharmacology
- Humans
- Male
- Personality Inventory
- Pyrimidinones - diagnostic use
- Receptors, Serotonin - drug effects, physiology
- Reference Values
- Self-Injurious Behavior - drug therapy, physiopathology, radionuclide imaging
- Tomography, Emission-Computed
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