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| Research article summary (published 22 Jan 2003): |
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Dynamics of the hippocampus during encoding and retrieval of face-name pairs.
Full Abstract
The medial temporal lobe (MTL) is critical in forming new memories, but how subregions within the MTL carry out encoding and retrieval processes in humans is unknown. Using new high-resolution functional magnetic resonance imaging (fMRI) acquisition and analysis methods, we identified mnemonic properties of different subregions within the hippocampal circuitry as human subjects learned to associate names with faces. The cornu ammonis (CA) fields 2 and 3 and the dentate gyrus were active relative to baseline only during encoding, and this activity decreased as associations were learned. Activity in the subiculum showed the same temporal decline, but primarily during retrieval. Our results demonstrate that subdivisions within the hippocampus make distinct contributions to new memory formation.
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Author information
Author/s: Zeineh, Michael M (MM); Engel, Stephen A (SA); Thompson, Paul M (PM); Bookheimer, Susan Y (SY);
Affiliation: Ahmanson-Lovelace Brain Mapping Center, UCLA School of Medicine, 660 Charles Young Drive South, Los Angeles, CA 90095-7085, USA.
Grants: AG 13308 (Agency:United States NIA) ; MH12167 (Agency:United States NIMH) ; MSTP GM08042 (Agency:United States OHS)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Science (New York, N.Y.) (Science), published in United States. (Language: eng)
Reference: 2003-Jan; vol 299 (issue 5606) : pp 577-80
Dates: Created 2003/01/24; Completed 2003/02/13; Revised 2007/11/14;
PMID: 12543980, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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