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| Research article summary (published 30 Mar 2003): |
Drug therapy of frontotemporal dementia.
Full Abstract
Frontal lobe dementia, or more generally frontotemporal dementia (FTD), includes several clinical entities and, although highly prevalent, lacks any codified therapeutic strategy. The present review is an attempt to depict the main neurochemical correlates of FTD and, as a consequence, to propose the most sound targets for symptomatic drugs. Large scale double-blind controlled clinical trials should be carried out to test any hypothesis:
serotonergic agents, glutamate neurotransmission enhancers, monoamine oxidase inhibitors. The recent discovery of tau gene mutations in FTD with Parkinsonism linked to chromosome 17 has reinforced the direct role attributed to abnormal tau proteins (hyperphosphorylation) and thus raised the possibility to target specifically these processes by drugs (aetiopathogenic compounds).Copyright 2003 John Wiley & Sons, Ltd.
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Author information
Author/s: Allain, Hervé (H); Bentué-Ferrer, Danièle (D); Tribut, Olivier (O); Mérienne, Marc (M); Belliard, Serge (S);
Affiliation: Laboratory of Clinical and Experimental Pharmacology Faculty of Medicine, University of Rennes I, 2, avenue du Pr. Léon Bernard, CS 34317, F-35043 Rennes cedex, France. Herve.Allain(-atsign-)univ-rennes1.fr
Journal and publication information
Publication Type: Journal Article; Review
Journal: Human psychopharmacology (Hum Psychopharmacol), published in England. (Language: eng)
Reference: 2003-Apr; vol 18 (issue 3) : pp 221-5
Dates: Created 2003/04/02; Completed 2003/08/22; Revised 2008/03/06;
PMID: 12672175, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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