Downregulation of striatal dopamine D2 receptors in advanced Parkinson's disease contributes to the development of motor fluctuation.

Full Abstract

The purpose of this study was to evaluate the contribution of the postsynaptic mechanism to the development of motor fluctuation in advanced Parkinson's disease (PD). We used 123I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in early levodopa-naïve PD, chronic PD with stable levodopa response, and advanced PD with fluctuating levodopa response. The basal ganglia/frontal cortex ratios at both hemispheres were calculated and averaged. PD patients with fluctuating levodopa response showed a significant decrease in striatal dopamine D2 receptor densities compared to those with early (1.57+/- 0.20 vs. 1.77 +/- 0.12, p = 0.009) or chronic stable PD (1.57 +/- 0.20 vs. 1.77 +/- 0.10, p = 0.024). We conclude that the decreased D2 receptor densities in advanced PD reduced the 'safety factor' for synaptic transmission and contributed to the development of motor fluctuation.Copyright 2002 S. Karger AG, Basel

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Author information

Author/s: Hwang, Wen-Jun (WJ); Yao, Wei-Jen (WJ); Wey, Shiaw-Pyng (SP); Shen, Lie-Hang (LH); Ting, Gann (G);

Affiliation: Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: European neurology (Eur Neurol), published in Switzerland. (Language: eng)

Reference: 2002-; vol 47 (issue 2) : pp 113-7

Dates: Created 2002/03/06; Completed 2002/04/22; Revised 2006/11/15;

PMID: 11844900, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Aged
Benzamides - diagnostic use
Corpus Striatum - drug effects; radionuclide imaging
Female
Humans
Iodine Radioisotopes
Levodopa - adverse effects; therapeutic use
Male

Male
Middle Aged
Motor Skills - drug effects
Neurologic Examination - drug effects
Parkinson Disease - drug therapy; radionuclide imaging
Pyrrolidines - diagnostic use
Receptors, Dopamine D2 - drug effects; physiology
Synaptic Transmission - drug effects; physiology
Tomography, Emission-Computed, Single-Photon

Associated Chemicals: Benzamides (0) ; Iodine Radioisotopes (0) ; Levodopa (0) ; Pyrrolidines (0) ; Receptors, Dopamine D2 (0) ; 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide (84226-06-2)

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