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| Research article summary (published 30 Dec 2002): |
Double-blind controlled investigation of bilateral prefrontal transcranial magnetic stimulation for the treatment of resistant major depression.
Full Abstract
BACKGROUND:
The efficacy and safety of bilateral prefrontal repetitive transcranial magnetic stimulation (rTMS) for treating resistant major depression were examined in a double-blind, placebo-controlled study.
METHOD:
Nineteen medication-resistant depressed subjects were randomly assigned to 3 weeks of active or sham rTMS. Effects on mood and neuropsychological function were assessed.
RESULTS:
Both groups improved significantly in mood over the 3 weeks, but there was no significant difference between active and sham treatments. There were no significant neuropsychological effects.
CONCLUSIONS:
Bilateral rTMS was not superior to sham in treating resistant depression in this pilot study, but caused no neuropsychological impairment.
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Author information
Author/s: Loo, C K (CK); Mitchell, P B (PB); Croker, V M (VM); Malhi, G S (GS); Wen, W (W); Gandevia, S C (SC); Sachdev, P S (PS);
Affiliation: Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales, Randwick, Australia.
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal: Psychological medicine (Psychol Med), published in England. (Language: eng)
Reference: 2003-Jan; vol 33 (issue 1) : pp 33-40
Dates: Created 2003/01/22; Completed 2003/04/15; Revised 2006/11/15;
PMID: 12537034, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
Comments and Corrections
CommentIn: Psychol Med. 2003 Jan;33(1):7-13. (PMID: 12537031)
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