 |
| Research article summary (published 30 Jul 2003): |
|
Free Full Text! See links below |
Dose-related effect of sevoflurane sedation on higher control of eye movements and decision making.
Full Abstract
BACKGROUND:
Saccadic latency may provide an objective method to assess sedative doses of anaesthetic on cortical oculomotor mechanisms and decision making.
METHODS:
We tested the effects of random doses of 0, 0.1, 0.2 and 0.3 MAC sevoflurane in six subjects, in a double-blind study using two measures of behavioural impairment:
saccadic latency and stop signal reaction time (SSRT) in a countermanding task.
RESULTS:
Saccadic latency and SSRT both increased with increasing doses of sevoflurane. In both measures, reciprocal reaction time was linearly related to dose in each subject:
all but two of the twelve regression coefficients were statistically significant (P<0.05). In one subject, SSRT was significantly more sensitive than simple latency (P<0.05); for the others there was no significant difference.
CONCLUSION:
Measurements of this kind could potentially provide estimates of cortical effects of sevoflurane sedation, and give a clinically useful measure of cognitive fitness.
Learn Faster Today Improve your study skills
Author information
Author/s: Nouraei, S A R (SA); De Pennington, N (N); Jones, J G (JG); Carpenter, R H S (RH);
Affiliation: University Department of Anaesthesia, Level 4, Addenbrooke's Hospital, Cambridge UK.
Journal and publication information
Publication Type: Clinical Trial; Controlled Clinical Trial; Journal Article
Journal: British journal of anaesthesia (Br J Anaesth), published in England. (Language: eng)
Reference: 2003-Aug; vol 91 (issue 2) : pp 175-83
Dates: Created 2003/07/24; Completed 2003/09/09; Revised 2004/11/17;
PMID: 12878614, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.