Research article summary (published 29 Apr 2003):

Dorsolateral prefrontal lobe activation declines significantly with age--functional NIRS study.

Full Abstract

Dorsolateral prefrontal cortex (DLPF) activation in response to cognitive paradigms engaging working memory was quantitatively evaluated using functional near infrared spectroscopy (fNIRS) in cognitively normal individuals across the age spectrum (20-90 years; 8 females, 52 males). DLPF activation score (DAS) demonstrated a significant decline (r(2) = -0561, p < 0.05) as a function of age. The study indicates that blood flow response associated with DLPF activation declines as a function of age in cognitively normal individuals and that fNIRS can be used as a convenient, portable tool for assessing such activation.

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Author information

Author/s: Kwee, Ingrid L (IL); Nakada, Tsutomu (T);

Affiliation: Department of Neurology, University of California, Davis, VANCHCS, 150 Muir Road, Martinez, CA 94553, USA. ilkwee(-atsign-)ucdavis.edu

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Journal of neurology (J Neurol), published in Germany. (Language: eng)

Reference: 2003-May; vol 250 (issue 5) : pp 525-9

Dates: Created 2003/05/08; Completed 2003/07/25; Revised 2006/11/15;

PMID: 12736729, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Aged, 80 and over Aging - physiology Cognition - physiology Female Humans

Humans Magnetic Resonance Imaging Male Middle Aged Prefrontal Cortex - blood supply; physiology Psychomotor Performance - physiology Spectroscopy, Near-Infrared - methods

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