 |
| Research article summary (published 30 Dec 2002): |
Dopaminergic modulation of visual-spatial working memory in Parkinson's disease.
Full Abstract
Visual-spatial working memory (WM) impairment is frequently associated with the early stage of Parkinson's disease (PD). The aim of this study was to evaluate the performance of a group of PD patients in visual-spatial and visual-object WM tasks and to investigate the effect of administering the dopaminergic agonist apomorphine (experiment 1) or the dopamine precursor L-dopa (experiment 2) on the performance of tests assessing these functions. To study WM processes, the PD patients and age-matched normal controls were given an n-back task paradigm. In both experiments, the PD patients were submitted to two evaluations:
one after a 12-hour therapy washout and the other 15 min after a subcutaneous infusion of apomorphine (average 0.04 mg/kg) or 20/30 min after L-dopa intake (200 mg p.o.). The apomorphine infusion had a worsening effect on reaction times in both visual-spatial and visual-object WM tasks, but it did not influence performance accuracy. Instead, L-dopa administration had a ameliorative effect on accuracy and reaction times in both visual-spatial and visual-object tasks. These results highlight the role of dopamine in the modulation of the WM function in PD patients.Copyright 2003 S. Karger AG, Basel
Learn Faster Today Improve your study skills
Author information
Author/s: Costa, Alberto (A); Peppe, Antonella (A); Dell'Agnello, Grazia (G); Carlesimo, Giovanni Augusto (GA); Murri, Luigi (L); Bonuccelli, Ubaldo (U); Caltagirone, Carlo (C);
Affiliation: IRCCS, Fondazione Santa Lucia, Università di Roma Tor Vergata, Italia. memolab@hsantalucia.it
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Dementia and geriatric cognitive disorders (Dement Geriatr Cogn Disord), published in Switzerland. (Language: eng)
Reference: 2003-; vol 15 (issue 2) : pp 55-66
Dates: Created 2003/02/04; Completed 2003/03/28; Revised 2008/03/24;
PMID: 12566593, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.