Research article summary:

Disturbed monitoring and response inhibition in patients with Gilles de la Tourette syndrome and co-morbid obsessive compulsive disorder.

Abstract Extract:
OBJECTIVE: Fronto-striatal dysfunction has been discussed as underlying symptoms of Tourette syndrome (TS) with co-morbid Obsessive Compulsive Disorder (OCD). This suggests possible impairments of executive functions in this disorder, which were ... (Full abstract text below)

Published 2003 in Journal: Behav Neurol (Language : eng)

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1. Behav Neurol. 2003 ;14(1-2):29-37

Disturbed monitoring and response inhibition in patients with Gilles de la Tourette syndrome and co-morbid obsessive compulsive disorder.

Müller SV, Johannes S, Wieringa B, Weber A, Müller-Vahl K, Matzke M, Kolbe H, Dengler R, Münte TF

Department of Clinical Neuropsychology, Otto-von-Guericke University Magdeburg, Box 4120, 39016 Magdeburg, Germany. sandra.mueller@nat.uni-magdeburg.de

OBJECTIVE: Fronto-striatal dysfunction has been discussed as underlying symptoms of Tourette syndrome (TS) with co-morbid Obsessive Compulsive Disorder (OCD). This suggests possible impairments of executive functions in this disorder, which were therefore targeted in the present study. METHODS: A comprehensive series of neuropsychological tests examining attention, memory and executive functions was performed in a group of 14 TS/OCD in co-occurrence with OCD patients and a matched control group. RESULTS: While attentional and memory mechanisms were not altered, TS/OCS patients showed deficits in executive functions predominantly in the areas of response inhibition and action monitoring. CONCLUSIONS: These findings provide further evidence for a substantial impairment of the frontal-striatal-thalamic-frontal circuit. We propose that the deficits in monitoring, error detection and response inhibition constitute the major impairment of TS/OCD patients in the cognitive domain.

PMID : 12719636 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Sandra Verena	Müller	SV
Sönke	Johannes	S
Berdieke	Wieringa	B
Axel	Weber	A
Kirsten	Müller-Vahl	K
Mike	Matzke	M
Hans	Kolbe	H
Reinhard	Dengler	R
Thomas F	Münte	TF

Affiliation: Department of Clinical Neuropsychology, Otto-von-Guericke University Magdeburg, Box 4120, 39016 Magdeburg, Germany. sandra.mueller@nat.uni-magdeburg.de

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Category links from this article:

Adult
Female
Humans
Inhibition (Psychology)
Male
Neuropsychological Tests
Obsessive-Compulsive Disorder - complications, physiopathology, psychology
Task Performance and Analysis
Tourette Syndrome - complications, physiopathology, psychology

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