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| Research article summary (published 30 Dec 2001): |
Detecting latency differences in event-related BOLD responses: application to words versus nonwords and initial versus repeated face presentations.
Full Abstract
We introduce a new method for detecting differences in the latency of blood oxygenation level-dependent (BOLD) responses to brief events within the context of the General Linear Model. Using a first-order Taylor approximation in terms of the temporal derivative of a canonical hemodynamic response function, statistical parametric maps of differential latencies were estimated via the ratio of derivative to canonical parameter estimates. This method was applied to two example datasets:
comparison of words versus nonwords in a lexical decision task and initial versus repeated presentations of faces in a fame-judgment task. Tests across subjects revealed both magnitude and latency differences within several brain regions. This approach offers a computationally efficient means of detecting BOLD latency differences over the whole brain. Precise characterization of the hemodynamic latency and its interpretation in terms of underlying neural differences remain problematic, however.
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Author information
Author/s: Henson, R N A (RN); Price, C J (CJ); Rugg, M D (MD); Turner, R (R); Friston, K J (KJ);
Affiliation: Wellcome Department of Cognitive Neurology, Institute of Cognitive Neuroscience, University College London, Queen Square, London WC1N 3BG, United Kingdom. r.henson(-atsign-)ucl.ac.uk
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2002-Jan; vol 15 (issue 1) : pp 83-97
Dates: Created 2002/01/04; Completed 2002/03/20; Revised 2006/11/15;
PMID: 11771976, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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