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| Research article summary (published 30 Mar 2002): |
Delayed onset of inhibition of return in schizophrenia.
Full Abstract
Peripheral visual cues occuring before a subsequent target result in an almost immediate facilitatory and then a later inhibitory effect on target detection. In a detailed parametric investigation, the authors compared schizophrenic subjects (SCZ) and control subjects (CONT) to examine whether they showed any differences in the time course of these nonpredictive peripheral cuing effects. Subjects fixated a central position and made saccadic responses to visual targets. Targets were presented 10 degrees to the left or right of fixation and were preceded at various time intervals by visual cues. Targets occurred with equal probability in either the same position as the cue or in the opposite, uncued location, and 10 delay periods were used corresponding to stimulus onset asynchronies (SOAs) of 66, 79, 106, 133, 159, 226, 305, 505, 705, and 1000 ms. All subjects showed facilitation for short cue-target delays and inhibition of return (IOR) for longer delays. SCZ, however, showed an apparent shift in the time course of cuing effects in the form of a delayed onset of IOR. Using a task of reflexive orienting, these results support findings of a delayed rather than an absent inhibitory process in medicated SCZ.
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Author information
Author/s: Larrison-Faucher, Abigail (A); Briand, Kevin A (KA); Sereno, Anne B (AB);
Affiliation: W.M. Keck Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Anatomy University of Texas-Houston Medical School, 77030, USA. abigailfaucher(-atsign-)hotmail.com
Grants: R01 MH63340 (Agency:United States NIMH)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry), published in England. (Language: eng)
Reference: 2002-Apr; vol 26 (issue 3) : pp 505-12
Dates: Created 2002/05/09; Completed 2002/11/05; Revised 2007/11/14;
PMID: 11999901, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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