 |
| Research article summary (published 27 Feb 2003): |
|
Free Full Text! See links below |
Deep brain stimulation of the subthalamic nucleus enhances emotional processing in Parkinson disease.
Full Abstract
BACKGROUND:
High-frequency electrical stimulation of the subthalamic nucleus is a new and highly effective therapy for complications of long-term levodopa therapy and motor symptoms in advanced Parkinson disease (PD). Clinical observations indicate additional influence on emotional behavior.
METHODS:
Electrical stimulation of deep brain nuclei with pulse rates above 100 Hz provokes a reversible, lesioning-like effect. Here, the effect of deep brain stimulation of the subthalamic nucleus on emotional, cognitive, and motor performance in patients with PD (n = 12) was examined. The results were compared with the effects of a suprathreshold dose of levodopa intended to transiently restore striatal dopamine deficiency. Patients were tested during medication off/stimulation off (STIM OFF), medication off/stimulation on (STIM ON), and during the best motor state after taking levodopa without deep brain stimulation (MED).
RESULTS:
More positive self-reported mood and an enhanced mood induction effect as well as improvement in emotional memory during STIM ON were observed, while during STIM OFF, patients revealed reduced emotional performance. Comparable effects were revealed by STIM ON and MED. Cognitive performance was not affected by the different conditions and treatments.
CONCLUSIONS:
Deep brain stimulation of the subthalamic nucleus selectively enhanced affective processing and subjective well-being and seemed to be antidepressive. Levodopa and deep brain stimulation had similar effects on emotion. This finding may provide new clues about the neurobiologic bases of emotion and mood disorders, and it illustrates the important role of the basal ganglia and the dopaminergic system in emotional processing in addition to the well-known motor and cognitive functions.
Learn Faster Today Improve your study skills
Author information
Author/s: Schneider, Frank (F); Habel, Ute (U); Volkmann, Jens (J); Regel, Sabine (S); Kornischka, Jürgen (J); Sturm, Volker (V); Freund, Hans-Joachim (HJ);
Affiliation: Department of Psychiatry and Psychotherapy, University of Düsseldorf, Germany. frank.schneider(-atsign-)uni-duesseldorf.de
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Archives of general psychiatry (Arch Gen Psychiatry), published in United States. (Language: eng)
Reference: 2003-Mar; vol 60 (issue 3) : pp 296-302
Dates: Created 2003/03/07; Completed 2003/04/03; Revised 2006/11/15;
PMID: 12622663, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.