Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease.

Full Abstract

Hippocampal cholinergic neurostimulating peptide (HCNP) is involved in the phenotype development of the septo-hippocampal system. HCNP precursor protein (HCNP-pp) is known to interact with other molecules including phosphatidylethanolamine and Raf-1 kinase, and is also known as phosphatidylethanolamine-binding protein and raf kinase-inhibitory protein. To assess whether HCNP-pp is involved in the pathogenesis of Alzheimer disease (AD), the expression levels of its mRNA in the hippocampus of autopsy brains from patients with dementia (including AD and ischemic vascular dementia) were compared with those of non-demented control subjects. The in situ hybridization analysis revealed that the expression of HCNP-pp mRNA in patients with clinically late-onset AD was decreased in the hippocampal CA1 field, but not in the CA3 field or the dentate gyrus. The early-onset AD patients showed a wide range of expression levels in the hippocampal sub-regions. Northern blot analysis of HCNP-pp mRNA in brain tissue supported these observations. Since HCNP is known to stimulate the enzymatic activity of choline acetyltransferase in neurons, its low expression in the CAI field of AD patients may explain the downregulation of cholinergic neurons seen in these patients and may thus contribute to the pathogenic processes underlying AD.

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Author information

Author/s: Maki, Mina (M); Matsukawa, Noriyuki (N); Yuasa, Hiroyuki (H); Otsuka, Yasushi (Y); Yamamoto, Takayuki (T); Akatsu, Hiroyasu (H); Okamoto, Takashi (T); Ueda, Ryuzo (R); Ojika, Kosei (K);

Affiliation: Second Department of Internal Medicine, Medical School, Nagoya City University, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of neuropathology and experimental neurology (J Neuropathol Exp Neurol), published in United States. (Language: eng)

Reference: 2002-Feb; vol 61 (issue 2) : pp 176-85

Dates: Created 2002/02/20; Completed 2002/03/07; Revised 2006/11/20;

PMID: 11853019, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Aged, 80 and over
Aging - physiology
Alzheimer Disease - genetics; metabolism
Androgen-Binding Protein
Carrier Proteins - genetics; metabolism
Enzyme Inhibitors - metabolism
Female
Gene Expression
Hippocampus - cytology; metabolism

Hippocampus - cytology; metabolism
Humans
In Situ Hybridization
Male
Nerve Tissue Proteins - genetics; metabolism
Neurons - cytology; metabolism
Phosphatidylethanolamine Binding Protein
Phospholipid Transfer Proteins
RNA, Messenger - genetics; metabolism
Reproducibility of Results

Associated Chemicals: Androgen-Binding Protein (0) ; Carrier Proteins (0) ; Enzyme Inhibitors (0) ; Nerve Tissue Proteins (0) ; PEBP1 protein, human (0) ; Phosphatidylethanolamine Binding Protein (0) ; Phospholipid Transfer Proteins (0) ; RNA, Messenger (0)

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