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| Research article summary (published Dec 2002): |
Decreased activity in inferotemporal cortex during explicit memory: dissociating priming, novelty detection, and recognition.
Full Abstract
Studies of non-human primates have shown that activity in inferotemporal (IT) brain regions decrease over repeated stimulus exposure, a phenomenon known as repetition suppression. In the present study, repetition suppression was examined during recognition of personally experienced events (explicit memory). Brain activity was measured while subjects encoded and subsequently recognized scenic pictures. First, two recognition conditions were compared; one that mainly included familiar pictures and one that mainly included novel pictures. Responses derived from this contrast may reflect recognition memory, perceptual priming, or novelty detection. To test specifically for responses associated with recognition memory, subjects encoded a new set of pictures followed by two recognition tests. All test pictures had been presented during the course of the experiment, and the subjects identified pictures that appeared in the second encoding list. Since all pictures were familiar, repetition suppression was specifically associated with recognition memory. In the first contrast, relative change in brain activity was observed in inferotemporal, extra-striate, and hippocampal regions during recognition of familiar versus novel pictures. In the second contrast, decreased activity in IT cortex was found. The location of this region overlapped with that for the region identified in the first contrast, and a conjunction analysis showed that reduced activity in left IT cortex was common to both contrasts. These results suggest that repetition suppression in IT cortex reflects recognition memory, and that such a response is not a simple function of stimulus repetition but can be modulated by top-down processing.
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Author information
Author/s: Persson, Jonas (J); Habib, Reza (R); Nyberg, Lars (L);
Affiliation: Rotman Research Institute of Baycrest Centre, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada. jonas.persson(-atsign-)psy.umu.se
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Neuroreport (Neuroreport), published in England. (Language: eng)
Reference: 2002-Dec; vol 13 (issue 17) : pp 2181-5
Dates: Created 2002/12/18; Completed 2003/04/15; Revised 2006/11/15;
PMID: 12488793, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
Comments and Corrections
ErratumIn: Neuroreport. 2003 Feb 10;14(2):294.
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