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Research article summary:
Decision-making for termination of pregnancies with fetal anomalies: analysis of 53,000 pregnancies.
Abstract Extract:
OBJECTIVE: To evaluate the degree to which prenatal knowledge of fetal anomalies and sociodemographic characteristics determined outcome of 53,000 pregnancies. METHODS: Pregnancies were consecutively evaluated at a university hospital between 1984 and ... (Full abstract text below) Published 2002Feb
in Journal: Obstet Gynecol
(Language : eng)
Full Pubmed Extract
This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:
1. Obstet Gynecol.
2002 Feb;99(2):216-22
Decision-making for termination of pregnancies with fetal anomalies: analysis of 53,000 pregnancies.
Schechtman KB, Gray DL, Baty JD, Rothman SM
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
OBJECTIVE: To evaluate the degree to which prenatal knowledge of fetal anomalies and sociodemographic characteristics determined outcome of 53,000 pregnancies. METHODS: Pregnancies were consecutively evaluated at a university hospital between 1984 and 1997. The severity of anomalies was graded by using an ordinal scale, in which 0 was no anomalies, 1 was no impact on quality of life, 2 was little impact but possibly requiring medical therapy, 3 was serious impact on quality of life even with optimal medical therapy, and 4 was incompatible with life. RESULTS: The abortion rates for grades 1 and 3 anomalies increased from 0.9% to 72.5%, and 0.9% to 37.1% for central nervous system and non-central nervous system anomalies, respectively (P <.001). Multiple logistic regression showed that mothers without a high school education were more likely than those who completed high school to abort a normal pregnancy (odds ratio [OR] 1.62, 95% confidence interval [CI] 1.07, 2.45). In the 452 pregnancies in which there was one grade 3 anomaly, logistic regression also showed that the abortion rate decreased by 6% per year as maternal age decreased (OR 0.94, 95% CI 0.91, 0.97). CONCLUSIONS: The severity of anomalies directly correlates with abortion rates, but at similar degrees of severity, central nervous system anomalies are more likely to lead to abortion. Maternal level of education inversely correlates with likelihood of termination of a normal pregnancy, whereas maternal age directly correlates with pregnancy termination when serious anomalies are present. Serious congenital anomalies may disproportionately affect children from families with the youngest mothers because these mothers are likely to continue these pregnancies.
PMID : 11814500 [PubMed - Indexed for MEDLINE]
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Full Author Information
| First Name | LastName | Initials |
| Kenneth B | Schechtman | KB |
| Diana L | Gray | DL |
| Jack D | Baty | JD |
| Steven M | Rothman | SM |
Affiliation: Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
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MESH categories and related page links
This article was linked to the MESH categories shown on the left below. The links on the right are related Memletics pages.
Category links from this article:- Abortion, Induced - psychology, statistics & numerical data
- Adult
- Central Nervous System - abnormalities, embryology, ultrasonography
- Congenital Abnormalities - epidemiology, pathology, ultrasonography
- Decision Making
- Female
- Humans
- Illinois - epidemiology
- Logistic Models
- Missouri - epidemiology
- Pregnancy
- Pregnancy Outcome
- Severity of Illness Index
- Socioeconomic Factors
- Ultrasonography, Prenatal
| | Related Memletics topics: |
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