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| Research article summary (published 10 Jun 2003): |
Cyclooxygenase-2 in the hippocampus is up-regulated in Alzheimer's disease but not in variant Alzheimer's disease with cotton wool plaques in humans.
Full Abstract
We examined neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, and neuron densities in the CA1-4 of the hippocampus in three cases of Alzheimer's disease with cotton wool plaques (CWP-AD), 17 cases of typical Alzheimer's disease without CWPs (tAD), and 26 normal controls. Cyclooxygenase-2 expression was significantly increased in all of the CA1-4 in tAD, but not in any subdivision in CWP-AD, compared with controls. Cyclooxygenase-2 expression in tAD was also significantly up-regulated compared with that in CWP-AD in all subdivisions. Furthermore, neuron density in the hippocampus was not significantly reduced in CWP-AD cases compared with controls despite remarkable intra- and extraneuronal Abeta deposition. These findings suggest that unknown factors besides Abeta deposition are necessary for the cyclooxygenase-2 up-regulation and neurodegeneration in Alzheimer's disease.
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Author information
Author/s: Yokota, Osamu (O); Terada, Seishi (S); Ishizu, Hideki (H); Ishihara, Takeshi (T); Ujike, Hiroshi (H); Nakashima, Hanae (H); Nakashima, Yoshihiko (Y); Kugo, Aki (A); Checler, Frédéric (F); Kuroda, Shigetoshi (S);
Affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan. oyokota1(-atsign-)yahoo.co.jp
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Neuroscience letters (Neurosci Lett), published in Ireland. (Language: eng)
Reference: 2003-Jun; vol 343 (issue 3) : pp 175-9
Dates: Created 2003/05/28; Completed 2003/07/02; Revised 2006/11/15;
PMID: 12770691, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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