Complex predictive eye pursuit in monkey: a model system for cerebellar studies of skilled movement.

Full Abstract

Smooth pursuit eye movements provide a good model system for cerebellar studies of complex motor control in monkeys. First, the pursuit system exhibits predictive control along complex trajectories and this control improves with training. Second, the flocculus/paraflocculus region of the cerebellum appears to generate this control. Lesions impair pursuit and neural activity patterns are closely related to eye motion during complex pursuit. Importantly, neural responses lead eye motion during predictive pursuit and lag eye motion during non-predictable target motions that require visual control. The idea that flocculus/paraflocculus predictive control is non-visual is also supported by a lack of correlation between neural activity and retinal image motion during pursuit. Third, biologically accurate neural network models of the flocculus/paraflocculus allow the exploration and testing of pursuit mechanisms. Our current model can generate predictive control without visual input in a manner that is compatible with the extensive experimental data available for this cerebellar system. Similar types of non-visual cerebellar control are likely to facilitate the wide range of other skilled movements that are observed.

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Author information

Author/s: Kettner, R E (RE); Suh, M (M); Davis, D (D); Leung, H C (HC);

Affiliation: Department of Physiology, Neuroscience Institute, M211, Northwestern University Medical School, 303 East Chicago Ave., Chicago, IL 60611, USA. r-kettner(-atsign-)nwu.edu

Grants: P50 MH-48185 (Agency:NIMH NIH HHS) ; R01 EY-12984 (Agency:NEI NIH HHS) ; T32 DC-00015 (Agency:NIDCD NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review

Journal: Archives italiennes de biologie (Arch Ital Biol), published in Italy. (Language: eng)

Reference: 2002-Oct; vol 140 (issue 4) : pp 331-40

Dates: Created 2002/09/16; Completed 2003/01/22; Revised 2007/11/14;

PMID: 12228986, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Action Potentials - physiology
Animals
Cerebellum - physiology
Haplorhini - physiology
Humans
Models, Animal

Models, Animal
Models, Neurological
Motor Skills - physiology
Movement - physiology
Purkinje Cells - physiology
Pursuit, Smooth - physiology

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