 |
| Research article summary (published 30 Dec 2001): |
Comparison of risperidone with olanzapine in elderly patients with dementia and psychosis.
Full Abstract
STUDY
OBJECTIVES:
To compare the effects of risperidone and olanzapine on cognition in elderly patients with dementia and psychosis, and to compare the side effects of these drugs.
DESIGN:
Single-blind, multicenter, observational study.
SETTING:
Four rural nursing care facilities.
PATIENTS:
Nineteen elderly patients with dementia and psychosis.
INTERVENTION:
Eleven patients were treated with risperidone, eight with olanzapine.
MEASUREMENTS AND MAIN RESULTS:
Rating assessments were completed at baseline, 1 month, and 2 months. Simple paired and unpaired t tests determined between- and within-group differences. Social functioning, including activities of daily living, improved over baseline in both groups (p=0.03). Cognition declined significantly (p<0.05) in the risperidone group; comparatively more side effects occurred and blood pressure decreased (p<0.05) in the olanzapine group. When compared with each group cross-sectionally at baseline and end point, however, the two groups did not differ significantly.
CONCLUSION:
Improvements in social functioning in all 19 patients suggest that both risperidone and olanzapine may help improve functioning in elderly patients with dementia and psychosis. Cognitive and side effect profiles of these drugs may differ substantially. Further study is needed to determine patient subpopulations who may be able to tolerate one drug over another.
Learn Faster Today Improve your study skills
Author information
Author/s: Ellingrod, Vicki L (VL); Schultz, Susan K (SK); Ekstam-Smith, Karen (K); Kutscher, Eric (E); Turvey, Carolyn (C); Arndt, Stephan (S);
Affiliation: College of Pharmacy, University of Iowa, Iowa City, USA. vicki-ellingrod(-atsign-)uiowa.edu
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal: Pharmacotherapy (Pharmacotherapy), published in United States. (Language: eng)
Reference: 2002-Jan; vol 22 (issue 1) : pp 1-5
Dates: Created 2002/01/16; Completed 2002/06/28; Revised 2006/11/15;
PMID: 11794418, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.