Research article summary:

A comparison of latent inhibition and learned irrelevance pre-exposure effects in rabbit and human eyeblink conditioning.

Abstract Extract:
The learning of an association between a CS and a US can be retarded by unreinforced presentations of the CS alone (termed latent inhibition or LI) or by un-correlated presentations of the CS and US (termed learned irrelevance or LIRR). In rabbit ... (Full abstract text below)

Published 2002 Jul-Sep in Journal: Integr Physiol Behav Sci (Language : eng)

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1. Integr Physiol Behav Sci. 2002 Jul-Sep;37(3):188-214

A comparison of latent inhibition and learned irrelevance pre-exposure effects in rabbit and human eyeblink conditioning.

Allen MT, Chelius L, Masand V, Gluck MA, Myers CE, Schnirman G

Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA. allenm@cofc.edu

The learning of an association between a CS and a US can be retarded by unreinforced presentations of the CS alone (termed latent inhibition or LI) or by un-correlated presentations of the CS and US (termed learned irrelevance or LIRR). In rabbit eyeblink conditioning, there have been some recent failures to replicate LI. LIRR has been hypothesized as producing a stronger retardation effect than LI based on both empirical studies and computational models. In the work presented here, we examined the relative strength of LI and LIRR in eyeblink conditioning in rabbits and humans. In both species, a number of preexposure trials sufficient to produce LIRR failed to produce LI (Experiments 1 & 3). Doubling the number of CS pre-exposures did produce LI in rabbits (Experiment 2), but not in humans (Experiment 4). LI was demonstrated in humans only after manipulations including an increased inter-trial interval or ITI (Experiment 5). Overall, it appears that LIRR is a more easily producible pre-exposure retardation effect than LI for eyeblink conditioning in both rabbits and humans. Several theoretical mechanisms for LI including the conditioned attention theory, stimulus compression, novelty, and the switching theory are discussed as possible explanations for the differences between LIRR and LI. Overall, future work involving testing the neural substrates of pre-exposure effects may benefit from the use of LIRR rather than LI.

PMID : 12435211 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
M Todd	Allen	MT
Lori	Chelius	L
Vivek	Masand	V
Mark A	Gluck	MA
Catherine E	Myers	CE
Geoffrey	Schnirman	G

Affiliation: Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA. allenm@cofc.edu

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