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| Research article summary (published 30 May 2002): |
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Comparison of the effects of sevoflurane and propofol on cortical somatosensory evoked potentials.
Full Abstract
BACKGROUND:
Propofol (P) and sevoflurane (S) are potential anaesthetic agents if electrophysiological monitoring is required during spinal surgery. They allow rapid recovery and do not depress cortical somatosensory evoked potentials (SSEP) as much as other agents. The effects of these agents on SSEP have not been compared before.
METHODS:
Twenty-four patients were allocated randomly to receive either S (n = 12) or P (n = 12). SSEP evoked by electrical stimulation of the posterior tibial nerve at the ankle were recorded before anaesthesia. The cortical potential P40 was recorded (latency P40 and amplitudes N29P40 and P40N50). The anaesthetic concentration was adjusted gradually to obtain three predetermined ranges of values of bispectral index (BIS):
45-55, 35-45 and 25-35. For each range, a stable state was maintained for 10 min and SSEP were recorded.
RESULTS:
For the BIS 45-55 range, compared with preoperative values, P40 latency increased during S [mean change +2 (SD 0.6) ms] but not during P [+0.4 (0.2) ms (P = 0.12)] and both amplitudes (N29P40 and P40N50) decreased with S. Increasing S concentration caused a dose-dependent depression of SSEP. P did not have a statistically significant effect on the recordings and the signals remained stable in each BIS range.
CONCLUSION:
Sevoflurane affected SSEP recordings in a dose-dependent fashion. Propofol had a minimal effect on SSEP recordings.
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Author information
Author/s: Boisseau, N (N); Madany, M (M); Staccini, P (P); Armando, G (G); Martin, F (F); Grimaud, D (D); Raucoules-Aimé, M (M);
Affiliation: Department of Anaesthesiology, Nice School of Medicine, University of Nice-Sophia-Antipolis, Hôpital Archet II, 151 route Saint-Antoine de Ginestière, BP 3079, F-06202 Nice, CHU de Nice, France.
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial
Journal: British journal of anaesthesia (Br J Anaesth), published in England. (Language: eng)
Reference: 2002-Jun; vol 88 (issue 6) : pp 785-9
Dates: Created 2002/08/13; Completed 2002/09/09; Revised 2006/11/15;
PMID: 12173194, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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