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| Research article summary (published 27 Feb 2003): |
Comparing event-related and epoch analysis in blocked design fMRI.
Full Abstract
In this study we demonstrate that, even in blocked design fMRI, an event-related analysis may provide a more accurate model of the hemodynamic responses than an epoch-related analysis. This is because the temporal shape of the predicted response differs between the event-related and the epoch model, with the former reaching its peak sooner and returning to baseline later than the latter. We present data from a blocked design fMRI study of single word reading alternated with rest. Conventionally, such a design would be analyzed using an epoch analysis with boxcar regressors. However, here we used a combined model in which trials were modeled as both single events and epochs. This allowed us to estimate the variance in the BOLD signal that was explained by either the event-related or the epoch regressors having discounted the effect of the other. We found that, in a number of language regions, the event-related model explained changes in activity that were not accounted for by the epoch model. In addition, we show that the advantage of the event-related over epoch model was engendered by its early onset rather than its late offset, relative to the epoch model.
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Author information
Author/s: Mechelli, Andrea (A); Henson, Rik N A (RN); Price, Cathy J (CJ); Friston, Karl J (KJ);
Affiliation: Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London, WCIN 3BG, UK. andream(-atsign-)fil.ion.ucl.ac.uk
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2003-Mar; vol 18 (issue 3) : pp 806-10
Dates: Created 2003/04/01; Completed 2003/05/19; Revised 2007/11/15;
PMID: 12667857, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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