Comparative diagnostic utility of different MR modalities in mild cognitive impairment and Alzheimer's disease.

Full Abstract

This study compares the diagnostic accuracy of magnetic resonance (MR)-based hippocampal volumetry, single voxel (1)H MR spectroscopy ((1)H MRS) and MR diffusion-weighted imaging (DWI) measurements in discriminating patients with amnestic mild cognitive impairment (MCI), Alzheimer's disease (AD) and normally aging elderly. Sixty-one normally aging elderly, 24 MCI and 22 AD patients underwent MR-based hippocampal volumetry, (1)H MRS and DWI. (1)H MRS voxels were placed over both of the posterior cingulate gyri, and N-acetyl aspartate (NAA)/creatine (Cr), myoinositol (MI)/Cr and NAA/MI ratios were obtained. Apparent diffusion coefficient (ADC) maps were derived from DWI, and hippocampal borders were traced to measure hippocampal ADC. At 80% specificity, the most sensitive single measurement to discriminate MCI (79%) and AD (86%) from controls was hippocampal volumes. The most sensitive single measurement to discriminate AD from MCI was posterior cingulate gyrus NAA/Cr (67%). At high specificity (>85-90%), combinations of MR measures had superior diagnostic sensitivity compared with any single MR measurement for the AD vs. control and control vs. MCI comparisons. The MR measures that best discriminate more from less affected individuals along the cognitive continuum from normal to AD vary with disease severity. Selection of imaging measures used for clinical assessment or monitoring efficiency of therapeutic intervention should be tailored to the clinical stage of the disease.Copyright 2002 S. Karger AG, Basel

Learn Faster Today Improve your study skills

Author information

Author/s: Kantarci, Kejal (K); Xu, YueCheng (Y); Shiung, Maria M (MM); O'Brien, Peter C (PC); Cha, Ruth H (RH); Smith, Glenn E (GE); Ivnik, Robert J (RJ); Boeve, Bradley F (BF); Edland, Steven D (SD); Kokmen, Emre (E); Tangalos, Eric G (EG); Petersen, Ronald C (RC); Jack, Clifford R (CR);

Affiliation: Department of Diagnostic Radiology, Mayo Clinic, Rochester, Minn., USA.

Grants: AG06786 (Agency:United States NIA) ; AG11378 (Agency:United States NIA) ; AG16574 (Agency:United States NIA)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Dementia and geriatric cognitive disorders (Dement Geriatr Cogn Disord), published in Switzerland. (Language: eng)

Reference: 2002-; vol 14 (issue 4) : pp 198-207

Dates: Created 2002/11/04; Completed 2003/03/28; Revised 2008/03/24;

PMID: 12411762, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Aged, 80 and over
Alzheimer Disease - diagnosis; pathology
Cognition Disorders - diagnosis; pathology
Diagnosis, Differential
Female
Hippocampus - pathology

This article has not been indexed for related articles as yet, however you can still use the live related article search links below.

See 100+ related articles.