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| Research article summary (published 13 Aug 2002): |
Common prefrontal regions coactivate with dissociable posterior regions during controlled semantic and phonological tasks.
Full Abstract
One of the most ubiquitous findings in functional neuroimaging research is activation of left inferior prefrontal cortex (LIPC) during tasks requiring controlled semantic retrieval. Here we show that LIPC participates in the controlled retrieval of nonsemantic representations as well as semantic representations. Results also demonstrate that LIPC coactivates with dissociable posterior regions depending on the information retrieved:
activating with left temporal cortex during the controlled retrieval of semantics and with left posterior frontal and parietal cortex during the controlled retrieval of phonology. Correlation of performance to LIPC activation suggests a processing role associated with mapping relatively ambiguous stimulus-to-representation relationships during both semantic and phonological tasks. These findings suggest that LIPC participates in controlled processing across multiple information domains collaborating with dissociable posterior regions depending upon the kind of information retrieved.
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Author information
Author/s: Gold, Brian T (BT); Buckner, Randy L (RL);
Affiliation: Department of Psychology, Washington University, One Brookings Drive, St. Louis, MO 63130, USA. bgold(-atsign-)artsci.wustl.edu
Grants: MH57506 (Agency:United States NIMH)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Neuron (Neuron), published in United States. (Language: eng)
Reference: 2002-Aug; vol 35 (issue 4) : pp 803-12
Dates: Created 2002/08/26; Completed 2002/09/20; Revised 2007/11/14;
PMID: 12194878, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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