Research article summary:

Combining brains: a survey of methods for statistical pooling of information.

Abstract Extract:
More than one subject is scanned in a typical functional brain imaging experiment. How can the scientist make best use of the acquired data to map the specific areas of the brain that become active during the performance of different tasks? It is clear ... (Full abstract text below)

Published 2002Jun in Journal: Neuroimage (Language : eng)

Full Pubmed Extract

This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:

1. Neuroimage. 2002 Jun;16(2):538-50

Combining brains: a survey of methods for statistical pooling of information.

Lazar NA, Luna B, Sweeney JA, Eddy WF

Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.

More than one subject is scanned in a typical functional brain imaging experiment. How can the scientist make best use of the acquired data to map the specific areas of the brain that become active during the performance of different tasks? It is clear that we can gain both scientific and statistical power by pooling the images from multiple subjects; furthermore, for the comparison of groups of subjects (clinical patients vs healthy controls, children of different ages, left-handed people vs right-handed people, as just some examples), it is essential to have a "group map" to represent each population and to form the basis of a statistical test. While the importance of combining images for these purposes has been recognized, there has not been an organized attempt on the part of neuroscientists to understand the different statistical approaches to this problem, which have various strengths and weaknesses. In this paper we review some popular methods for combining information, and demonstrate the surveyed techniques on a sample data set. Given a combination of brain images, the researcher needs to interpret the result and decide on areas of activation; the question of thresholding is critical here and is also explored.

PMID : 12030836 [PubMed - Indexed for MEDLINE]

This information is obtained from the National Library of Medicine (NLM). Abstract text and other information may be subject to copyright. Type "NLM copyright" into Google for more information.

Full Author Information

First Name	LastName	Initials
Nicole A	Lazar	NA
Beatriz	Luna	B
John A	Sweeney	JA
William F	Eddy	WF

Affiliation: Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.

3rd Party provider links

Click the links below to go to related 3rd party information:

MESH categories and related page links

This article was linked to the MESH categories shown on the left below. The links on the right are related Memletics pages.

Links for this article

For links to places where you can get the full text of this article see links. Note there may be a subscription or fee required for access to the full text.

New! Using similar technology to this site, we have launched find-health-articles.com, targeting over 1 million health research article abstracts.

Here are some articles related to this one (by title keywords):

Spatiotemporal independent component analysis of event-related fMRI data using skewed probability density functions.

Parallel cascade recognition of exon and intron DNA sequences.

Integration of motion information during binocular rivalry.

Information-seeking patterns of dentists in Istanbul, Turkey.

The use of facial motion and facial form during the processing of identity.

Face versus non-face object perception and the other-race effect: a spatio-temporal event-related potential study.

Effects of ayahuasca on sensory and sensorimotor gating in humans as measured by P50 suppression and prepulse inhibition of the startle reflex, respectively.

Correspondence of event-related potential tomography and functional magnetic resonance imaging during language processing.

Brains rule! fun = learning = neuroscience literacy.

Association of parental involvement and social competence with school adjustment and engagement among sixth graders.

>>> Get more research article abstracts like these, or browse abstracts.

Keywords in this article:

acquired, activation, active, approaches, areas, attempt, basis, become, best, brain, children, clear, clinical, combination, combining, comparison, controls, critical, data, decide, demonstrate, different, essential, examples, experiment, functional, furthermore, gain, given, groups, handed, healthy, images, imaging, importance, information, interpret, left, map, methods, more, multiple, needs, neuroscientists, not, one, organized, paper, part, patients, people, performance, pooling, popular, population, power, problem, purposes, question, recognized, represent, researcher, result, review, right, sample, scanned, scientific, scientist, set, specific, statistical, strengths, subject, subjects, surveyed, tasks, techniques, test, thresholding, typical, understand, vs, weaknesses

Also, see our new free speed reading online course (beta version)