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| Research article summary (published 30 Jun 2003): |
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Cognitive strategies dependent on the hippocampus and caudate nucleus in human navigation: variability and change with practice.
Full Abstract
The human brain activity related to strategies for navigating in space and how it changes with practice was investigated with functional magnetic resonance imaging. Subjects used two different strategies to solve a place-learning task in a computer-generated virtual environment. One-half of the subjects used spatial landmarks to navigate in the early phase of training, and these subjects showed increased activation of the right hippocampus. The other half used a nonspatial strategy and showed, with practice, sustained increased activity within the caudate nucleus during navigation. Activation common to both groups was observed in the posterior parietal and frontal cortex. These results provide the first evidence for spontaneous variability and shift in neural mechanisms during navigation in humans.
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Author information
Author/s: Iaria, Giuseppe (G); Petrides, Michael (M); Dagher, Alain (A); Pike, Bruce (B); Bohbot, Véronique D (VD);
Affiliation: Douglas Hospital Research Center, McGill University, Verdun, Quebec, Canada, H4H 1R3.
Journal and publication information
Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)
Reference: 2003-Jul; vol 23 (issue 13) : pp 5945-52
Dates: Created 2003/07/04; Completed 2003/08/14; Revised 2006/11/15;
PMID: 12843299, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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