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| Research article summary (published 30 Dec 2001): |
Cognitive and sedative effects of benzodiazepine use.
Full Abstract
This paper reviews the effects of benzodiazepines (BZs) on the performance of tasks measuring human cognitive abilities. The paper reviews the most common cognitive side effects of BZs:
increased sedation, decreased attention, and anterograde amnesia. In particular, this paper focuses on recent findings regarding time course-related effects on BZ-induced deficits in explicit and implicit human memory performance. Specifically, we reviewed recent research indicating that both explicit memory and priming are impaired by BZs if the encoding task takes place near the time of the theoretical peak plasma concentrations of the drug. Although BZs also appear to increase objective and subjective sedation, as well as to impair attentional processing, these other cognitive impairments do not appear to fully account for the widespread memory deficits caused by BZ administration. The theoretical and clinical implications of benzodiazepine-induced memory impairments are discussed.
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Author information
Author/s: Buffett-Jerrott, S E (SE); Stewart, S H (SH);
Affiliation: Department of Psychology, Dalhousie University, Life Sciences Center, 1355 Oxford Street, Halifax, Nova Scotia, Canada B3H 4J1. sjerrott(-atsign-)is2.dal.ca
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Journal: Current pharmaceutical design (Curr Pharm Des), published in Netherlands. (Language: eng)
Reference: 2002-; vol 8 (issue 1) : pp 45-58
Dates: Created 2002/01/28; Completed 2002/03/19; Revised 2007/11/15;
PMID: 11812249, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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