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| Research article summary (published 22 Oct 2002): |
Cognitive mechanisms of nicotine on visual attention.
Full Abstract
Understanding nicotine's neurobiological and cognitive mechanisms may help explain both its addictive properties and potential therapeutic applications. As such, functional MRI was used to determine the neural substrates of nicotine's effects on a sustained attention (rapid visual information-processing) task. Performance was associated with activation in a fronto-parietal-thalamic network in both smokers and nonsmokers. Along with subtle behavioral deficits, mildly abstinent smokers showed less task-induced brain activation in the parietal cortex and caudate than did nonsmokers. Transdermal nicotine replacement improved task performance in smokers and increased task-induced brain activation in the parietal cortex, thalamus, and caudate, while nicotine induced a generalized increase in occipital cortex activity. These data suggest that nicotine improves attention in smokers by enhancing activation in areas traditionally associated with visual attention, arousal, and motor activation.
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Author information
Author/s: Lawrence, Natalia S (NS); Ross, Thomas J (TJ); Stein, Elliot A (EA);
Affiliation: Department of Psychiatry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Grants: DA09465 (Agency:NIDA NIH HHS) ; M01 00058 (Agency:PHS HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Neuron (Neuron), published in United States. (Language: eng)
Reference: 2002-Oct; vol 36 (issue 3) : pp 539-48
Dates: Created 2002/10/31; Completed 2002/11/26; Revised 2007/11/14;
PMID: 12408855, status: MEDLINE (last retrieval date: 12/26/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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