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| Research article summary (published 29 Jun 2003): |
Cognitive effects of nicotine in humans: an fMRI study.
Full Abstract
To elucidate the neural correlates of cognitive effects of nicotine, we examined behavioral performance and blood oxygenation level-dependent regional brain activity, using functional magnetic resonance imaging, during a parametric "n-back" task in healthy nonsmoking males after the administration of nicotine (12 microg/kg body weight) or saline. Nicotine, compared to placebo, improved accuracy (P = 0.008) in all active conditions (2%-11%), and had a load-specific effect on latency (P = 0.004; 43.78% decrease at the highest memory load). Within a network of parietal and frontal areas activated by the task (P < 0.05, corrected at the voxel level), nicotine produced an increased response (P < 0.05; uncorrected within the regions of interest) in the anterior cingulate, superior frontal cortex, and superior parietal cortex. It also produced an increased response in the midbrain tectum in all active conditions and in the parahippocampal gyrus, cerebellum, and medial occipital lobe during rest (P = 0.05; uncorrected). The present observations point to altered neuronal activity in a distributed neural network associated with on-line task monitoring and attention and arousal systems as underlying nicotine-related enhancement of attention and working memory in human subjects.
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Author information
Author/s: Kumari, Veena (V); Gray, Jeffrey A (JA); ffytche, Dominic H (DH); Mitterschiffthaler, Martina T (MT); Das, Mrigen (M); Zachariah, Elizabeth (E); Vythelingum, Goparlen N (GN); Williams, Steven C R (SC); Simmons, Andrew (A); Sharma, Tonmoy (T);
Affiliation: Department of Psychology, Institute of Psychiatry, King's College, London, UK. v.kumari(-atsign-)iop.kcl.ac.uk
Journal and publication information
Publication Type: Clinical Trial; Evaluation Studies; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2003-Jul; vol 19 (issue 3) : pp 1002-13
Dates: Created 2003/07/25; Completed 2003/09/09; Revised 2006/11/15;
PMID: 12880828, status: MEDLINE (last retrieval date: 12/26/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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