Cognitive effects of the dopamine receptor agonist pergolide.

Full Abstract

Although dopamine has been closely associated with prefrontal function, and with working memory in monkeys, the effects of dopamine agonists on human cognitive performance are poorly understood. We report the effects of a single dose of pergolide on young healthy subjects performing a variety of cognitive tests, including tests of memory and of frontal/executive function. Across this battery of tasks, the only tasks reliably affected by pergolide were delayed response tasks. Across four variants, we observed that the effect of pergolide was more beneficial for subjects with greater working memory capacities. We discuss this in light of the variable results obtained from previous studies of dopamine agonists in human subjects.

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Author information

Author/s: Kimberg, Daniel Y (DY); D'Esposito, Mark (M);

Affiliation: Department of Neurology, Hospital of the University of Pennsylvania, 3W Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA.

Journal and publication information

Publication Type: Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: Neuropsychologia (Neuropsychologia), published in England. (Language: eng)

Reference: 2003-; vol 41 (issue 8) : pp 1020-7

Dates: Created 2003/04/01; Completed 2003/06/04; Revised 2006/11/15;

PMID: 12667537, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Analysis of Variance
Association Learning - drug effects
Cognition - drug effects; physiology
Dopamine Agonists - pharmacology
Dose-Response Relationship, Drug
Female
Humans

Male
Memory, Short-Term - drug effects
Neuropsychological Tests
Pergolide - pharmacology
Psychomotor Performance
Reaction Time - drug effects
Reading
Space Perception - drug effects
Verbal Learning - drug effects

Associated Chemicals: Dopamine Agonists (0) ; Pergolide (66104-22-1)

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