Cognitive deficits in major depression.

Full Abstract

Major depression is a mood disorder that is often accompanied by the impairment of cognitive functions. Although suggestive, the large range of existing neuropsychological, neuropsychiatric, and, lately, neuroimaging investigations have not yet given a consistent picture of the psychological and biological disturbances involved in this psychiatric disorder. The present study of the cognitive functions in depression was part of an extensive investigation, including neuropsychological testing, psychiatric examination, and neuroimaging. A representative sample of 40 severely depressed hospitalized patients and a group of 49 closely matched control subjects were tested with an extensive neuropsychological test battery. Results, corrected for various confounding factors, confirmed the current notion that depressed patients suffer from wide-spread cognitive impairments. The group analysis did not allow any hypothesis on a possible pattern to the dysfunctions, but heterogeneity in the test performances calls for further analysis of the data in patient subgroups in relation to neuroimaging results.

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Author information

Author/s: Ravnkilde, Barbara (B); Videbech, Poul (P); Clemmensen, Karin (K); Egander, Annette (A); Rasmussen, Niels Anton (NA); Rosenberg, Raben (R);

Affiliation: Institute for Basic Psychiatric Research, Department of Biological Psychiatry, Psychiatric Hospital, Arhus, Risskov, Denmark. bje(-atsign-)psykiatri.aaa.dk

Journal and publication information

Publication Type: Journal Article

Journal: Scandinavian journal of psychology (Scand J Psychol), published in England. (Language: eng)

Reference: 2002-Jul; vol 43 (issue 3) : pp 239-51

Dates: Created 2002/08/19; Completed 2002/09/18; Revised 2004/11/17;

PMID: 12184479, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Aged
Analysis of Variance
Attention
Case-Control Studies
Cognition Disorders - complications
Denmark
Depressive Disorder - complications; pathology

Depressive Disorder - complications; pathology
Female
Humans
Intelligence
Male
Memory
Middle Aged
Psychomotor Performance
Statistics, Nonparametric

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