Cognitive decline among female estrogen users in nursing homes.

Full Abstract

BACKGROUND:
Clinical and epidemiological research has been done regarding the potential therapeutic benefit of estrogen in outpatients with and without dementia; however, the effects of estrogen therapy on cognition in elderly nursing home patients have not been previously examined.

METHODS:
This retrospective cohort study compared 191 women estrogen users with 663 women nonestrogen users, matched according to age, nursing home facility, year of assessment, and baseline level of cognitive function. The outcome was decline in cognition, measured by the Cognitive Performance Scale, over a minimum follow-up period of 6 months.

RESULTS:
No significant difference was found in the rate of cognitive decline among estrogen users and nonusers.

CONCLUSIONS:
Estrogen therapy administered to nursing home residents is not associated with a reduction in cognitive decline. This study lends further support to recent controlled clinical trials that found no benefit for estrogen treatment on cognition in outpatients with dementia.

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Author information

Author/s: Ott, Brian R (BR); Belazi, Dea (D); Lapane, Kate L (KL);

Affiliation: Department of Clinical Neurosciences, Brown University, Providence, Rhode Island, USA. Brian_Ott(-atsign-)mhri.org

Grants: AG 17957-01 (Agency:NIA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences (J Gerontol A Biol Sci Med Sci), published in United States. (Language: eng)

Reference: 2002-Sep; vol 57 (issue 9) : pp M594-8

Dates: Created 2002/08/28; Completed 2002/09/23; Revised 2007/11/14;

PMID: 12196497, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Cognition - drug effects; physiology
Cognition Disorders - drug therapy
Estrogens - pharmacology; therapeutic use
Female

Associated Chemicals: Estrogens (0)

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