Research article summary:

Cognitive and brain function in schizotypal personality disorder.

Abstract Extract:
Schizotypal personality disorder, a diagnosis defined partially in terms of a genetic relatedness to schizophrenia, has begun to receive extensive investigative study. While the exact etiologic relationship between schizotypal personality disorder and ... (Full abstract text below)

Published 2002Mar in Journal: Schizophr Res (Language : eng)

Full Pubmed Extract

This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:

1. Schizophr Res. 2002 Mar;54(1-2):157-67

Cognitive and brain function in schizotypal personality disorder.

Siever LJ, Koenigsberg HW, Harvey P, Mitropoulou V, Laruelle M, Abi-Dargham A, Goodman M, Buchsbaum M

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA. larry.siever@med.va.gov

Schizotypal personality disorder, a diagnosis defined partially in terms of a genetic relatedness to schizophrenia, has begun to receive extensive investigative study. While the exact etiologic relationship between schizotypal personality disorder and schizophrenia remains to be determined, three models have been considered: (1) the two may be distinct disorders, (2) they may be essentially identical disorders but expressed with different degrees of severity, or (3) they may be related disorders with a partially overlapping etiology that might account for the many similarities yet the lack of psychosis or severe deficits in schizotypal individuals. Some of the recent research in the structural and functional neuroanatomy, neurochemistry, cognitive function, and pharmacology of schizotypal personality disorder is reviewed with citation of the most recent findings from our laboratory and others. Both schizotypal and schizophrenic subjects appear to show abnormalities in temporal lobe volume, but schizotypal subjects do not appear to show the volumetric decreases in frontal cortex that schizophrenic patients evidence. Abnormalities in thalamic nuclei parallel these findings-the pulvinar, which projects to temporal association and sensory cortices, is reduced in both disorders, but the mediodorsal nucleus, which projects extensively to the frontal cortex, is reduced in schizophrenic patients but not in schizotypal patients. Functional imaging studies suggest that there may be abnormalities in frontal activation in both disorders, but that schizotypal individuals can recruit alternative regions to accomplish tasks requiring frontal lobe activation that may help compensate. Imaging studies of the subcortex including FDG/PET imaging of metabolic activity during a verbal learning task, SPECT imaging studies which measure binding of IBZM and its displacement following amphetamine administration, and plasma HVA determinations following 2-deoxyglucose administration all suggest the possibility of relatively reduced dopaminergic subcortical activity in schizotypal individuals compared to schizophrenic patients. Cognitive function is also impaired in the areas of working memory, verbal learning, and attention in schizotypal patients, as in schizophrenic patients, and they may be particularly susceptible to cognitive tasks with high context dependence, as in schizophrenia. Preliminary trials of catecholaminergic agents suggest that these agents may be able to improve these impaired cognitive functions.

PMID : 11853990 [PubMed - Indexed for MEDLINE]

This information is obtained from the National Library of Medicine (NLM). Abstract text and other information may be subject to copyright. Type "NLM copyright" into Google for more information.

Full Author Information

First Name	LastName	Initials
Larry J	Siever	LJ
Harold W	Koenigsberg	HW
Philip	Harvey	P
Vivian	Mitropoulou	V
Marc	Laruelle	M
Anissa	Abi-Dargham	A
Marianne	Goodman	M
Monte	Buchsbaum	M

Affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA. larry.siever@med.va.gov

3rd Party provider links

Click the links below to go to related 3rd party information:

MESH categories and related page links

This article was linked to the MESH categories shown on the left below. The links on the right are related Memletics pages.

Category links from this article:

Benzamides - diagnostic use
Brain - abnormalities, blood supply, physiopathology
Cognition Disorders - diagnosis, etiology
Contrast Media
Humans
Magnetic Resonance Imaging
Neuropsychological Tests
Pyrrolidines - diagnostic use
Schizotypal Personality Disorder - complications, physiopathology
Tomography, Emission-Computed, Single-Photon

Links for this article

For links to places where you can get the full text of this article see links. Note there may be a subscription or fee required for access to the full text.

New! Using similar technology to this site, we have launched find-health-articles.com, targeting over 1 million health research article abstracts.

Here are some articles related to this one (by title keywords):

Manipulation: description, identification and ambiguity.

Encoding, learning, and spatial updating of multiple object locations specified by 3-D sound, spatial language, and vision.

Brief report: cognitive functioning in children with Tourettes syndrome with and without comorbid ADHD.

Utilization of emotion cues in male and female offenders with antisocial personality disorder: results from a lexical decision task.

Recognition memory for faces in schizophrenia patients and their first-degree relatives.

Quality of treatment following police detention of mentally disordered offenders.

Prevalence and risk and protective factors related to disordered eating behaviors among adolescents: relationship to gender and ethnicity.

Personality trait development from age 12 to age 18: longitudinal, cross-sectional, and cross-cultural analyses.

Personality and quality of life: the importance of optimism and goal adjustment.

Enhanced intensity dependence as a marker of low serotonergic neurotransmission in borderline personality disorder.

>>> Get more research article abstracts like these, or browse abstracts.

Keywords in this article:

able, abnormalities, accomplish, account, activation, activity, administration, agents, alternative, amphetamine, appear, areas, association, attention, begun, binding, catecholaminergic, citation, cognitive, compared, compensate, considered, context, cortex, cortices, decreases, deficits, defined, degrees, deoxyglucose, dependence, determinations, determined, diagnosis, different, disorder, disorders, displacement, distinct, dopaminergic, essentially, etiologic, etiology, evidence, exact, expressed, extensive, extensively, fdg, findings, following, frontal, functional, genetic, help, high, hva, ibzm, identical, imaging, impaired, improve, including, individuals, investigative, laboratory, lack, learning, lobe, many, measure, mediodorsal, memory, metabolic, models, neuroanatomy, neurochemistry, not, nuclei, nucleus, others, overlapping, parallel, partially, particularly, patients, personality, pet, pharmacology, plasma, possibility, preliminary, projects, psychosis, pulvinar, receive, recent, recruit, reduced, regions, relatedness, relationship, relatively, remains, requiring, research, reviewed, schizophrenia, schizophrenic, schizotypal, sensory, severe, severity, similarities, spect, structural, studies, study, subcortex, subcortical, subjects, suggest, susceptible, tasks, temporal, terms, thalamic, three, trials, two, verbal, volume, volumetric, working, yet

Also, see our new free speed reading online course (beta version)