Cognitive and behavioral deficits in premature graduates of intensive care.

Full Abstract

A substantial number of VLBW graduates of intensive care develop cognitive and behavioral problems, even in the absence of neuroimaging abnormalities. Although this article has highlighted the potential, important, contributing role of medical and stressful, neonatal, environmental conditions to the development of these deficits, it is not all-encompassing, and there are additional prenatal (ie, in utero stress, drug exposure) and neonatal (ie, infectious) contributing factors. The long-term, outcome data presented in this article are pertinent to the more mature, VLBW infant, and it remains unclear and critically important to delineate the long-term, neurobehavioral outcome of those extremely low birth-weight survivors born at the cutting limit of viability.

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Author information

Author/s: Perlman, Jeffrey M (JM);

Affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9063, USA. jeffrey.perlman(-atsign-)utsouthwestern.edu

Journal and publication information

Publication Type: Journal Article; Review

Journal: Clinics in perinatology (Clin Perinatol), published in United States. (Language: eng)

Reference: 2002-Dec; vol 29 (issue 4) : pp 779-97

Dates: Created 2003/01/08; Completed 2003/01/31; Revised 2008/11/21;

PMID: 12516746, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Basal Ganglia - growth & development; injuries
Brain - growth & development
Causality
Child Behavior Disorders - etiology; prevention & control
Child Psychology
Cognition Disorders - etiology; prevention & control
Developmental Disabilities - etiology; prevention & control
Health Facility Environment - standards
Hippocampus - growth & development; injuries

Hippocampus - growth & development; injuries
Humans
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature, Diseases - physiopathology; psychology; therapy
Infant, Very Low Birth Weight
Intensive Care, Neonatal - methods; standards
Noise - adverse effects
Treatment Outcome

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