Research article summary:

Cholinesterase inhibitor treatment alters the natural history of Alzheimers disease.

Abstract Extract:
OBJECTIVE: To describe the effect of cholinesterase inhibitors (CEIs) on the natural course of Alzheimers disease (AD). METHODS: The short and long term effects of CEIs were evaluated in 135 patients with probable Alzheimers disease relative to 135 ... (Full abstract text below)

Published 2002Mar in Journal: J Neurol Neurosurg Psychiatry (Language : eng)

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1. J Neurol Neurosurg Psychiatry. 2002 Mar;72(3):310-4

Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease.

Lopez OL, Becker JT, Wisniewski S, Saxton J, Kaufer DI, DeKosky ST

Alzheimer's Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

OBJECTIVE: To describe the effect of cholinesterase inhibitors (CEIs) on the natural course of Alzheimer's disease (AD). METHODS: The short and long term effects of CEIs were evaluated in 135 patients with probable Alzheimer's disease relative to 135 patients who were never exposed to CEIs matched by age, education, duration of the symptoms, and cognitive status. We measured 1 year change in cognitive and functional performance, and the likelihood of arriving at each of four end points: (1) mini mental state examination (MMSE) of 9 or lower, (2) Blessed dementia rating scale for activities of daily living of 12 or higher, (3) nursing home admission, and (4) death, over an average 3 years of observation (36.7 (SD 21.5) months). RESULTS: Patients on CEIs were better cognitively and functionally after 1 year compared with those patients who never used CEIs. A proportional hazard analysis with CEI use as a time dependent covariate showed that the use of CEIs decreased the risk of nursing home admission. There was no association, however, between use of CEIs and time to cognitive and functional end points, or to death. CONCLUSIONS: This observational study showed that there was an initial cognitive and functional benefit from the use of CEIs in Alzheimer's disease, which waned as the disease progressed. However, the results suggest that there is a long term beneficial effect of the use of CEIs, as indicated by the delay in admission to nursing homes.

PMID : 11861686 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
O L	Lopez	OL
J T	Becker	JT
S	Wisniewski	S
J	Saxton	J
D I	Kaufer	DI
S T	DeKosky	ST

Affiliation: Alzheimer's Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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