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| Research article summary (published 29 Jun 2003): |
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Changing plans: a high density electrical mapping study of cortical control.
Full Abstract
High density electrical mapping was used to index event-related brain activity in subjects performing parametric variations of the "AX"-type continuous performance task (AX-CPT) that differentially challenge control, and informative control conditions. In the AX-CPT, subjects must use context, created by a cue stimulus, to guide response to a target. Diseases such as schizophrenia and attention deficit hyperactivity disorder (ADHD) are associated with impaired AX-CPT performance. Event-related potentials (ERP) were analyzed as a function of both global and local stimulus context. The topographical analysis revealed that well-defined ERP are elicited under conditions where subjects must override a prepotent response. Activation patterns related to overriding a prepotent response (Go to No-Go) differed markedly from those associated with overriding a prepotent non-response (No-Go to Go). Dipole source mapping suggested that withholding a prepotent response is reflected primarily in anterior cingulate/dorsolateral prefrontal cortex activity during the 350-450 ms latency range following presentation of the No-Go. In contrast, preparing to respond is reflected in parietal (including area BA 40) activity during the same latency range, followed by a prolonged frontal negativity (contingent negative variation; CNV). Similar patterns of activation were observed whether the changes in preparation were triggered by cue or target stimuli, though target-elicited potentials peaked earlier.
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Author information
Author/s: Dias, Elisa C (EC); Foxe, John J (JJ); Javitt, Daniel C (DC);
Affiliation: Cognitive Neurophysiology Laboratory, Program in Cognitive Neurosciences and Schizophrenia, The Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA. dias(-atsign-)nki.rfmh.org
Grants: MH 49334 (Agency:United States NIMH) ; MH 63434 (Agency:United States NIMH) ; R03 MH063434-02 (Agency:United States NIMH)
Journal and publication information
Publication Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Cerebral cortex (New York, N.Y. : 1991) (Cereb Cortex), published in United States. (Language: eng)
Reference: 2003-Jul; vol 13 (issue 7) : pp 701-15
Dates: Created 2003/06/20; Completed 2003/08/15; Revised 2007/11/14;
PMID: 12816885, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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