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| Research article summary (published 30 Dec 2001): |
Changes of P300 elicited during a Working Memory test in Individuals with depersonalization-derealization experiences.
Full Abstract
BACKGROUND/AIM:
The P300 component of Event-Related Potentials (ERPs) is related to fundamental aspects of cognitive functions, such as Working Memory (WM) and attention allocation. Deficits in these domains have been implicated in the pathophysiology of depersonalization-derealization (DD). The present study focused on the P300 elicited during a WM test in transient DD experiences.
METHODS:
Fifteen subjects with transient DD experiences were matched for age, sex and educational level to an equal number of healthy controls. Both groups were submitted to a computerized version of the digit span Wechsler batteries. P300 was measured during the anticipatory period of this test. All participants completed the Dixon self-rating questionnaire.
RESULTS:
In relation to the control group, the subjects with transient DD experiences showed significantly decreased amplitudes of P300 at central posterior brain areas. Concerning memory performance, the groups did not differ significantly.
CONCLUSIONS:
These findings may indicate that subjects with transient DD experiences manifest altered aspects of information processing, as reflected by P300 amplitudes elicited during a WM test. Additionally, P300 might serve as a valuable investigative tool for a more comprehensive understanding of the neurobiological substrate of DD.Copyright 2002 S. Karger AG, Basel
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Author information
Author/s: Papageorgiou, Charalaos (C); Ventouras, Erricos (E); Uzunoglu, Nikolaos (N); Rabavilas, Andreas (A); Stefanis, Costas (C);
Affiliation: Department of Psychiatry, Eginition Hospital, University of Athens, Athens, Greece. panchris(-atsign-)otenet.gr
Journal and publication information
Publication Type: Clinical Trial; Journal Article
Journal: Neuropsychobiology (Neuropsychobiology), published in Switzerland. (Language: eng)
Reference: 2002-; vol 46 (issue 2) : pp 70-5
Dates: Created 2002/10/14; Completed 2002/11/25; Revised 2004/11/17;
PMID: 12378123, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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