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| Research article summary (published 30 Dec 2002): |
Changes in Mini-Mental State Exam in community-dwelling older persons over 6 years: relationship to health and neuropsychological measures.
Full Abstract
Although cognitive screening test scores change with advanced age, the significance of these changes (particularly decline in score) needs to be defined in terms of general health and neuropsychological functioning. Such analysis was undertaken in a subgroup of 287 healthy older men (mean age at baseline = 70.7 years) from the Western Collaborative Group Study, an ongoing cardiovascular and aging research project. Time from baseline to follow-up study averaged 6.0 years (SD = 0.5 years). Mini-Mental State Examination (MMSE) scores indicated that 15% of participants declined by three or more points (a 1+ standard deviation change among all change scores), 5% of participants improved by three or more points, and 80% of the sample remained within two points of their initial score. In health terms, decliners were significantly older, less active at follow-up, rated their health more poorly, and reported more depressive symptoms than non-decliners. Decliners also performed more poorly on several neuropsychological tests administered at follow-up. Results suggest that a decline of three or more points on the MMSE in community-dwelling, older persons without acute illness may signify important changes in health and cognition.Copyright 2003 S. Karger AG, Basel
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Author information
Author/s: Eslinger, Paul J (PJ); Swan, Gary E (GE); Carmelli, Dorit (D);
Affiliation: Department of Medicine (Division of Neurology), Penn State University College of Medicine, Hershey, Pa., USA. peslinger(-atsign-)psu.edu
Grants: AG09341 (Agency:United States NIA)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Neuroepidemiology (Neuroepidemiology), published in Switzerland. (Language: eng)
Reference: -2003 Jan-Feb; vol 22 (issue 1) : pp 23-30
Dates: Created 2003/02/04; Completed 2003/03/12; Revised 2007/11/14;
PMID: 12566950, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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