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| Research article summary (published 27 Feb 2002): |
Changes in explicit memory associated with early dementia in adults with Down's syndrome.
Full Abstract
BACKGROUND:
A modified version of the Selective Reminding Test (SRT) (Buschke 1973) was used to examine the changes in memory that occur with early-stage dementia of the Alzheimer's type (DAT) in adults with intellectual disability (ID) and Down's syndrome (DS), and to compare these changes to those occurring with 'normal' ageing.
METHOD:
Hierarchical linear modelling analyses showed steep declines in the performance of participants who had met the criteria for the onset of DAT. Non-demented participants also showed declines in performance which were related to their age. However, the absolute magnitude of these declines was consistent with a 'normal' ageing pattern and not with undetected dementia.
RESULTS:
In analysing the specific memory components that are compromised, the present authors found that participants with early-stage DAT showed severely diminished long-term storage and retrieval processing abilities compared to their non-demented peers. Notably, these declines preceded other symptoms of dementia, in most cases by more than a full year and sometimes by as much as 3 years.
CONCLUSIONS:
Thus, the present results clearly confirm that memory processes are affected during early dementia in adults with DS, and that the SRT has promise as a clinical tool.
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Author information
Author/s: Krinsky-McHale, S J (SJ); Devenny, D A (DA); Silverman, W P (WP);
Affiliation: New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314-6399, USA. sjmchale(-atsign-)worldnet.att.net
Grants: P01 AG11531 (Agency:United States NIA) ; P01 HD 22634 (Agency:United States NICHD) ; P01 HD35897 (Agency:United States NICHD) ; R01 AG14771 (Agency:United States NIA)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Journal of intellectual disability research : JIDR (J Intellect Disabil Res), published in England. (Language: eng)
Reference: 2002-Mar; vol 46 (issue Pt 3) : pp 198-208
Dates: Created 2002/03/18; Completed 2002/05/28; Revised 2007/11/14;
PMID: 11896805, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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