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| Research article summary (published 30 May 2002): |
Changes in cerebellar activation pattern during two successive sequences of saccades.
Full Abstract
The changes in the cerebellar activation pattern of two successive fMRI scanning runs were determined for visually guided to-and-fro saccades in 12 healthy volunteers familiar with the study paradigm. Group and single subject-analyses revealed a constant activation of the paramedian cerebellar vermis (uvula, tonsils, tuber, folium/declive), which reflects constant ocular motor activity in both runs. A significant decrease in activation of the cerebellar hemispheres found in the second run is best explained by either a decrease in attention or the effects of motor optimization and learning. The significant, systematic changes of the cerebellar activation pattern in two successive runs were not expected, because the ocular motor task was simple, familiar, and highly automated. These findings indicate that similar effects may bias other cerebellar activation studies, in which sensorimotor tasks are repeated in a single session.Copyright 2002 Wiley-Liss, Inc.
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Author information
Author/s: Stephan, Thomas (T); Mascolo, Andrea (A); Yousry, Tarek A (TA); Bense, Sandra (S); Brandt, Thomas (T); Dieterich, Marianne (M);
Affiliation: Center for Sensorimotor Research, Department of Neurology, Ludwig-Maximilians University, Munich, Germany. tstephan(-atsign-)nefo.med.uni-muenchen.de
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Human brain mapping (Hum Brain Mapp), published in United States. (Language: eng)
Reference: 2002-Jun; vol 16 (issue 2) : pp 63-70
Dates: Created 2002/04/15; Completed 2002/07/26; Revised 2006/11/15;
PMID: 11954056, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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