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| Research article summary (published 29 Jun 2003): |
Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia.
Full Abstract
We recently noted a profound decline in brain sulfatides (ST) in subjects who died with incipient dementia due to Alzheimer's disease. Herein, we measured ST levels in cerebrospinal fluid in cognitively normal elderly and in subjects with mild cognitive impairment due to incipient demenia of the Alzheimer type. There was a significant decrease in cerebrospinal fluid ST and in the ST to phosphatidylinositol ratio in MCI subjects. The ST to phosphatidylinositol ratio accurately differentiated very mildly impaired subjects from controls on an individual basis. The cerebrospinal fluid ST to phosphatidylinositol ratio may be a very useful biomarker for the earliest clinical stage of Alzheimer's disease.
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Author information
Author/s: Han, Xianlin (X); Fagan, Anne M (AM); Cheng, Hua (H); Morris, John C (JC); Xiong, Chengjie (C); Holtzman, David M (DM);
Affiliation: Division of Bioorganic Chemistry and Molecular Pharmacology, and the Departments of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. xianlin(-atsign-)pcg.wustl.edu
Grants: AG00861 (Agency:United States NIA) ; AG03991 (Agency:United States NIA) ; AG05681 (Agency:United States NIA) ; M01 RR00036 (Agency:United States NCRR)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Annals of neurology (Ann Neurol), published in United States. (Language: eng)
Reference: 2003-Jul; vol 54 (issue 1) : pp 115-9
Dates: Created 2003/07/02; Completed 2003/08/20; Revised 2007/11/14;
PMID: 12838527, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
Comments and Corrections
CommentIn: Ann Neurol. 2003 Jul;54(1):7-8. (PMID: 12838515)
ErratumIn: Ann Neurol. 2003 Nov;54(5):693.
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