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| Research article summary (published 30 May 2003): |
Cerebral networks linked to the event-related potential P300.
Full Abstract
P300 is an event-related potential that is elicited by an oddball paradigm. In several neuropsychiatric diseases, differences in latencies and amplitude compared to healthy subjects have been reported. Because of its clinical significance, several investigations have tried to elucidate the intracranial origins of the P300 component. In the present study we could demonstrate a network of P300 generators. Investigated were 15 healthy subjects with an acoustical oddball paradigm within a fMRI block design, which enabled us to exclude attention or acoustical processing effects. The inferior and middle frontal, superior temporal, lower parietal cortex, the insula and the anterior cingulum were significantly activated symmetrical in both hemispheres.
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Author information
Author/s: Horn, Helge (H); Syed, Nadeem (N); Lanfermann, Heinrich (H); Maurer, Konrad (K); Dierks, Thomas (T);
Affiliation: Dept. of Psychiatric Neurophysiology, University Hospital of Clinical Psychiatry Bern, Bolligenstr. 111, Bern, Switzerland. horn(-atsign-)puk.unibe.ch
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: European archives of psychiatry and clinical neuroscience (Eur Arch Psychiatry Clin Neurosci), published in Germany. (Language: eng)
Reference: 2003-Jun; vol 253 (issue 3) : pp 154-9
Dates: Created 2003/08/07; Completed 2003/09/17; Revised 2006/11/15;
PMID: 12904980, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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