 |
| Research article summary (published 30 Mar 2002): |
Cerebral blood flow and cognitive dysfunction after coronary surgery.
Full Abstract
BACKGROUND:
Postoperative cognitive dysfunction after cardiac surgery has been attributed both to embolic events and periods with reduced cerebral perfusion. We investigated whether cognitive dysfunction after coronary surgery is associated with changes in regional cerebral blood flow (CBF) using single photon emission computed tomography.
METHODS:
Before surgery and at discharge, 15 coronary surgery patients were studied. Global and regional CBF were measured using a brain-dedicated single photon emission computed tomography scanner, and neuropsychological testing with seven subtests was performed. Postoperative cognitive dysfunction was defined as a Z score above 2. Normative single photon emission computed tomography data were available from 26 healthy age-matched controls.
RESULTS:
Preoperative global CBF was significantly lower in patients compared with controls (53.7 versus 46.1 mL/100 g/min, p = 0.006). After surgery, global CBF significantly decreased in the patient group (46.1 versus 38.6 mL/100 g/min, p = 0.0001). No significant differences were detected in regional CBF. Cognitive dysfunction was identified in 4 of the 15 patients (26.7%, 95% CI 7.8% to 55.1%). No correlation was found between the neuropsychological Z score and global or regional CBF.
CONCLUSIONS:
The significant decrease in CBF after coronary surgery was uniformly distributed and was not correlated to postoperative cognitive dysfunction.
Learn Faster Today Improve your study skills
Author information
Author/s: Abildstrom, Hanne (H); Høgh, Peter (P); Sperling, Bjørn (B); Moller, Jakob T (JT); Yndgaard, Stig (S); Rasmussen, Lars S (LS);
Affiliation: Department of Anesthesia, Rigshospitalet, Copenhagen University Hospital, Denmark. habil(-atsign-)rh.dk
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: The Annals of thoracic surgery (Ann Thorac Surg), published in United States. (Language: eng)
Reference: 2002-Apr; vol 73 (issue 4) : pp 1174-8; discussion 1178-9
Dates: Created 2002/05/08; Completed 2002/05/21; Revised 2006/11/15;
PMID: 11996259, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.