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| Research article summary (published 30 Aug 2003): |
Caspase activation in the limbic cortex of subjects with early Alzheimer's disease.
Full Abstract
We investigated the cleavage of caspase-3, a marker of apoptosis, in the medial temporal lobe of older subjects with minimal cognitive deficits and low CERAD/intermediate Braak scores, that is, clinicopathological descriptors of early Alzheimer's disease (AD). The activation of caspase-3 was studied with immunoprecipitation-mass spectroscopy and immunocytochemistry, including colocalization with paired helical filaments in the neuropil and perikarya. We found that caspase-3 is activated in the parahippocampal gyrus in subjects with mild AD and that this event is silenced in more advanced illness. Caspase-3 immunoreactivity has a tangle-like appearance that coevolves with paired helical filament pathology within neurons. We propose that activation of apoptosis may occur very early in the medial temporal lobe in AD.
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Author information
Author/s: Gastard, Myriam C (MC); Troncoso, Juan C (JC); Koliatsos, Vassilis E (VE);
Affiliation: Division of Neuropathology, Department of Neurology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205-2196, USA.
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Annals of neurology (Ann Neurol), published in United States. (Language: eng)
Reference: 2003-Sep; vol 54 (issue 3) : pp 393-8
Dates: Created 2003/09/03; Completed 2003/10/23; Revised 2006/11/15;
PMID: 12953274, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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