Research article summary:

Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration.

Abstract Extract:
OBJECTIVE: The authors goal was to compare regional brain volumes in depressed elderly subjects with those of nondepressed elderly subjects by using voxel-based morphometry. METHOD: They used statistical parametric mapping to analyze magnetic resonance ... (Full abstract text below)

Published 2002Aug in Journal: Am J Psychiatry (Language : eng)

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1. Am J Psychiatry. 2002 Aug;159(8):1424-7

Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration.

Bell-McGinty S, Butters MA, Meltzer CC, Greer PJ, Reynolds CF, Becker JT

Neuropsychology Research Program, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA.

OBJECTIVE: The authors' goal was to compare regional brain volumes in depressed elderly subjects with those of nondepressed elderly subjects by using voxel-based morphometry. METHOD: They used statistical parametric mapping to analyze magnetic resonance imaging scans from 30 depressed patients 59 to 78 years old and 47 nondepressed comparison subjects 55 to 81 years old. RESULTS: Depressed patients had smaller right hippocampal volume than comparison subjects. The volume of the hippocampal-entorhinal cortex was inversely associated with the number of years since the first lifetime episode of depression. CONCLUSIONS: These data provide further evidence of structural brain abnormalities in geriatric depression, particularly in patients with a longer course of illness.

PMID : 12153839 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Sandra	Bell-McGinty	S
Meryl A	Butters	MA
Carolyn Cidis	Meltzer	CC
Phil J	Greer	PJ
Charles F	Reynolds	CF
James T	Becker	JT

Affiliation: Neuropsychology Research Program, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA.

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Category links from this article:

Age Factors
Age of Onset
Aged
Brain - anatomy & histology
Depressive Disorder - diagnosis
Entorhinal Cortex - anatomy & histology
Female
Functional Laterality
Geriatric Assessment - statistics & numerical data
Hippocampus - anatomy & histology
Humans
Magnetic Resonance Imaging - statistics & numerical data
Male
Psychiatric Status Rating Scales - statistics & numerical data
Time Factors

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