Research article summary:

Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive-compulsive disorder.

Abstract Extract:
OBJECTIVE: The study was designed to elucidate regional brain metabolic changes according to a treatment and their relationship with neuropsychological performance changes in obsessive-compulsive disorder (OCD). METHOD: Cerebral glucose metabolic rates ... (Full abstract text below)

Published 2003Apr in Journal: Acta Psychiatr Scand (Language : eng)

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1. Acta Psychiatr Scand. 2003 Apr;107(4):291-7

Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive-compulsive disorder.

Kang DH, Kwon JS, Kim JJ, Youn T, Park HJ, Kim MS, Lee DS, Lee MC

Department of Psychiatry, Seoul National University Hospital, Seoul, Korea.

OBJECTIVE: The study was designed to elucidate regional brain metabolic changes according to a treatment and their relationship with neuropsychological performance changes in obsessive-compulsive disorder (OCD). METHOD: Cerebral glucose metabolic rates were repeatedly measured before and after treatment in 10 patients with OCD using [18F]-2-fluoro-deoxyglucose positron emission tomography (PET). They were compared on a voxel-basis, and the correlations were counted between the regional metabolic changes and the degree to improvement on the neuropsychological assessments. RESULTS: After treatment, the patients showed significant (P < 0.005, two-tailed) regional metabolic changes in multiple brain areas involving frontal-subcortical circuits and parietal-cerebellar networks. Especially, the metabolic changes of the putamen, the cerebellum, and the hippocampus were significantly correlated with the improvement of the immediate- and delayed-recall scores of the Rey-Osterrieth Complex Figure Test (RCFT). CONCLUSION: These results suggest a possibility that metabolic changes of frontal-subcortical and parietal-cerebellar circuit changes may underlie cognitive improvements in patients with OCD.

PMID : 12662252 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
D-H	Kang	DH
J S	Kwon	JS
J-J	Kim	JJ
T	Youn	T
H-J	Park	HJ
M S	Kim	MS
D S	Lee	DS
M C	Lee	MC

Affiliation: Department of Psychiatry, Seoul National University Hospital, Seoul, Korea.

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