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| Research article summary (published 30 Dec 2001): |
Beta-CIT-SPECT combined with UPDRS appears to distinguish different parkinsonian conditions.
Full Abstract
OBJECTIVES:
An earlier study in l-dopa responding patients with idiopathic Parkinson's disease documented that progressive nigro-striatal degeneration shown with single photon emission computed tomography (SPECT) and the cocain analog iodine-123-beta-CIT (beta-CIT) correlated linearly with increasing motor scores in the Unified Parkinson's Disease Rating Scale (UPDRS). Here we have extended the study to include 2 tremor patients with mild parkinsonism, 2 poor l-dopa responders with parkisonism and 2 non l-dopa responders with severe parkinsonism.
METHODS:
SPECT scanning was performed 20 h after injection of beta-CIT and UPDRS was done at the time of beta-CIT injection.
RESULTS:
All patients in the present study showed less nigro-striatal degeneration in relation to UPDRS motor scores than the patients with idiopathic Parkinson's disease.
CONCLUSION:
The results suggest that the the combination of beta-CIT-SPECT and UPDRS motor scores has the potential to differentiate idiopathic Parkinson's disease from other parkinsonian conditions.
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Author information
Author/s: Sjøholm, H (H); Sundsfjord, J (J); Mellgren, S I (SI);
Affiliation: Department of Neurology, University Hospital, Tromsø, Norway.
Journal and publication information
Publication Type: Journal Article
Journal: Acta neurologica Scandinavica (Acta Neurol Scand), published in Denmark. (Language: eng)
Reference: 2002-Jan; vol 105 (issue 1) : pp 5-7
Dates: Created 2002/03/20; Completed 2002/05/03; Revised 2006/08/16;
PMID: 11903101, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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