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| Research article summary (published 12 Nov 2002): |
Behavioral and neural analysis of extinction.
Full Abstract
The neural mechanisms by which fear is inhibited are poorly understood at the present time. Behaviorally, a conditioned fear response may be reduced in intensity through a number of means. Among the simplest of these is extinction, a form of learning characterized by a decrease in the amplitude and frequency of a conditioned response when the conditioned stimulus that elicits it is repeatedly nonreinforced. Because clinical interventions for patients suffering from fear dysregulation seek to inhibit abnormal, presumably learned fear responses, an understanding of fear extinction is likely to inform and increase the efficacy of these forms of treatment. This review considers the behavioral, cellular, and molecular literatures on extinction and presents the most recent advances in our understanding while identifying issues that require considerable further research.
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Author information
Author/s: Myers, Karyn M (KM); Davis, Michael (M);
Affiliation: Department of Psychology, Emory University, Atlanta, GA 30322, USA.
Grants: MH 47840 (Agency:United States NIMH) ; MH 52384 (Agency:United States NIMH) ; MH 57250 (Agency:United States NIMH) ; MH 59906 (Agency:United States NIMH)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review
Journal: Neuron (Neuron), published in United States. (Language: eng)
Reference: 2002-Nov; vol 36 (issue 4) : pp 567-84
Dates: Created 2002/11/20; Completed 2002/12/19; Revised 2007/11/14;
PMID: 12441048, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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