Research article summary:

Behavioral conditioning of immunosuppression is possible in humans.

Abstract Extract:
Behavioral conditioned immunosuppression has been described in rodents as the most impressive demonstration of brain-to-immune system interaction. To analyze whether behavioral conditioned immunosuppression is possible in humans, healthy subjects in this ... (Full abstract text below)

Published 2002Dec in Journal: FASEB J (Language : eng)

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1. FASEB J. 2002 Dec;16(14):1869-73

Behavioral conditioning of immunosuppression is possible in humans.

Goebel MU, Trebst AE, Steiner J, Xie YF, Exton MS, Frede S, Canbay AE, Michel MC, Heemann U, Schedlowski M

Department of Medical Psychology, University of Essen, Essen, Germany.

Behavioral conditioned immunosuppression has been described in rodents as the most impressive demonstration of brain-to-immune system interaction. To analyze whether behavioral conditioned immunosuppression is possible in humans, healthy subjects in this double-blind, placebo-controlled study were conditioned in four sessions over 3 consecutive days, receiving the immunosuppressive drug cyclosporin A as an unconditioned stimulus paired with a distinctively flavored drink (conditioned stimulus) each 12 h. In the next week, re-exposure to the conditioned stimulus (drink), but now paired with placebo capsules, induced a suppression of immune functions as analyzed by the IL-2 and IFN-gamma mRNA expression, intracellular production, and in vitro release of IL-2 and IFN-gamma, as well as lymphocyte proliferation. These data demonstrate for the first time that immunosuppression can be behaviorally conditioned in humans.

PMID : 12468450 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Marion U	Goebel	MU
Almuth E	Trebst	AE
Jan	Steiner	J
Yu F	Xie	YF
Michael S	Exton	MS
Stilla	Frede	S
Ali E	Canbay	AE
Martin C	Michel	MC
Uwe	Heemann	U
Manfred	Schedlowski	M

Affiliation: Department of Medical Psychology, University of Essen, Essen, Germany.

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