 |
| Research article summary (published 15 Apr 2003): |
Auditory selective attention modulated by tryptophan depletion in humans.
Full Abstract
To elucidate serotonin modulation of selective attention, 13 volunteers (21-30 years) were studied in two sessions, 5 h after either acute tryptophan depletion (ATD) that decreases brain serotonin synthesis, or control-mixture ingestion (randomized, double-blind, cross-over design). Simultaneous electroencephalogram and magnetoencephalogram were measured during dichotic listening of two concurrent trains of standard and deviant tones. Subjects counted the deviants presented to one ear and ignored those presented to the other ear. ATD lowered plasma total tryptophan by 75% and free tryptophan by 39%. ATD suppressed the amplitude enhancement of P50 and N1 to selectively attended tones, but did not affect the later aspects of processing negativity. The P50 latencies were increased after ATD, irrespective of attention. In conclusion, serotonin may regulate attentional modulation of early cortical stimulus processing.
Learn Faster Today Improve your study skills
Author information
Author/s: Ahveninen, Jyrki (J); Jääskeläinen, Iiro P (IP); Pennanen, Sirpa (S); Liesivuori, Jyrki (J); Ilmoniemi, Risto J (RJ); Kähkönen, Seppo (S);
Affiliation: Department of Psychology, PO Box 9, FIN-00014 University of Helsinki, Helsinki, Finland. jyrki.ahveninen@helsinki.fi
Journal and publication information
Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal: Neuroscience letters (Neurosci Lett), published in Ireland. (Language: eng)
Reference: 2003-Apr; vol 340 (issue 3) : pp 181-4
Dates: Created 2003/04/03; Completed 2003/05/30; Revised 2006/11/15;
PMID: 12672536, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.